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. 2022 Jan 26;9:818568. doi: 10.3389/fmed.2022.818568

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Copyright © 2022 AlRyalat, Ertel, Seibold and Kahook.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow chart of the different combinations from the three glaucoma diagnostic facets (functional, structural, and intraocular pressure) as they relate to the major clinical trials in glaucoma. GLT, The Glaucoma Laser Trial; AGIS, The Advanced Glaucoma Intervention Study; CNTGS, Collaborative Normal-Tension Glaucoma Study; OHTS, Ocular Hypertension Treatment Study; EMGT, Early Manifest Glaucoma Trial; EGPS, The European Glaucoma Prevention Study; LoGTS, Low-Pressure Glaucoma Treatment Study; UKGTS, UK Glaucoma Treatment Study.