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Cell cycle progression. (A) Example of targets of cell cycle arrest at the G2/M transition and G1/S transition in tumor cells for the development of liver cancer drugs. ATM, ataxia telangiectasia mutated; ATR, ATM and Rad3-related; Chk, human checkpoint kinase; ERK, extracellular signal-regulated kinase. (B) Example of targets of cell cycle arrest at the G1/S transition in tumor cells for the development of liver cancer drugs. pRB, retinoblastoma protein; CDK, cyclin-dependent kinase.
