Table 1.

The targets and pathways of natural compounds in the process of arresting cell cycle progression in HCC.

Phase of cell cycle	Target	Signalling pathway	Natural compound	Chinese medicine	Reference
G2/M	cyclin A, Cdk1/4, and caspase-3/8/9	Caspase pathway	Asparanin A	Asparagus officinalis L	(44)
G2/M	cyclin B1, cdc2/25c, and Myt1	PIK3/Akt pathway	Chalcone Flavokawain B	Rhizomes of Alpinia plants	(45)
G2/M	P38 and p53	PIK3/Akt, p38 MAPK, and p53 pathways	Curcumin	Curcumalonga L	(46)
G2/M	cyclin B1 and cdc2	Ras/Raf/MAPK pathway	Wentilactone B (WB)	Aspergillus wentii EN-48	(47)
S	cdk/cyclin	ERK pathway	Hispolon	Phellinus igniarius	(55)
S	p21	p21 pathway	Chrysanthemum indicum extract	Chrysanthemum indicum	(56)
S	p21	p21 pathway	Mirabilis himalaica extract	Mirabilis himalaica	(57)
S	p21	p21 pathway	Juglanthraquinone C	Juglans mandshurica Maxim	(58)
G1	p-Rb/E2F-1		Iso-suillin		(59)
G1	p53	p53 pathway	Resveratrol	Grape	(46)
G1	p53	p53 pathway	TanshinoneII-A	Salvia miltiorrhiza root	(46)
G1	p-Rb, p21	STAT3 pathway	Silibinin	milk thistle (Silybum marianum)	(46)
S and G2/M	CDK1 and Cyclin B1	Caspase-dependent and -independent pathways	2’-epi-2’-O-Acetylthevetin B	Cerbera manghas L	(60)
G1 and G2/M	Bcl family and cytochrome c	Caspase pathway	Naringenin	Citrus fruits	(61)