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. 2022 Jan 26;11:812264. doi: 10.3389/fonc.2021.812264

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Copyright © 2022 Jia, Wang, Sang, Liu, Gao, Jiang and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of the PEITC/BMN 673 combination were PARP1-dependent. (A) PARP-trapping assay. Western blot analysis of PARP1 in chromatin fractions in the HGSOC cell lines (OVSAHO, SNU119, COV362 and OVCAR4) treated as indicated. Histone 3 was used as a loading control. (B) Western blot analysis of PARP1 in the HGSOC cell lines (OVSAHO, SNU119 and COV362) with or without shRNA-mediated PARP1 knockdown. Vinculin was used as a loading control. (C) Clonogenic survival assay of the HGSOC cell lines treated with or without the PEITC/BMN 673 combination. (D) Cell cycle analysis of the HGSOC cells treated as indicated for 24 hours was determined by PI staining and FACS analysis. Data are shown as mean ± S.D. The statistical differences in the percentage of G2/M cells were indicated. n.s., not significant; *p < 0.05; **p < 0.01; ***p < 0.001 (Student’s t-test).