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. 2022 Jan 26;11:808300. doi: 10.3389/fonc.2021.808300

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Copyright © 2022 Park, Kim, Hallis, Choi and Kwak

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of CD133 with NRF2 and clinical outcome of colorectal cancer patients. (A) Overall survival rates of colorectal patients with altered (n = 17) vs unaltered (n = 509) CD133 gene. (B) Overall survival rates of colorectal patients with altered (n = 24) vs unaltered (n = 502) NRF2 or CD133 gene. (C) Overall survival rates of colorectal patients with high CD133 (n = 52) vs unaltered (474) mRNA levels. Plots generated by cBioPortal were modified. (D–F) Correlation of CD133 mRNA levels (high CD133, n = 52; unaltered CD133, n = 454; low CD133, n = 20) with NRF2 (D), NQO1 (E), and PIK3CA (F) mRNA levels in colorectal tumors. Values are given in (RNA Seq V2 RSEM) in log2. Plots generated by cBioPortal were modified.