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. 2021 Dec 27;40(4):1141–1157. doi: 10.1007/s10555-021-10012-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Determinants of SCLC metabolism. The metabolism of SCLC cells is regulated not only by the so-called cell-intrinsic factors, such as genetic background and activated signaling pathways, but also by several other factors that include molecular subtype, metabolic phenotype, tumor microenvironment, intratumoral heterogeneity, and spatiotemporal evolution [79]. Interactions between more or all determinants can be present in the tumor as it is indicated by arrows on the rim of the figure (it cannot be accurately visualized in a 2D figure, but interactions among non-adjacent factors can also be present at the same time)