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. 2021 Dec 21;40(4):1073–1091. doi: 10.1007/s10555-021-10007-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — pmCiC is expressed in cancer cells and cancer-associated stroma in human tissues. Immunohistochemical expression of pmCIC investigated in a primary non-small cell lung carcinoma (NSCLC; A) showing moderate cytoplasmic signal in the carcinoma glands (DAB, magnification 100x; — 100 µm). B shows a colon carcinoma gland metastatic to the lung with a scattered expression of pmCIC (DAB, magnification 100x; — 50 µm). Strong uniform expression of a metastatic breast cancer (C) in a liver biopsy (DAB; magnification 200x — 50 µm). Weak expression of pmCIC in a metastasis (D) of a carcinoma in a lymph node (DAB, magnification 100x; — 100 µm). Figure E shows a solid pancreatic carcinoma (c) with surrounding desmoplastic stroma displaying a moderate (➔) as well as small vessels (DAB, magnification 100x; — 100 µm). Figure F shows a pancreatic cancer (c) complex with a prominent expression of pmCIC in small vessels (v) (DAB, magnification 100x; — 100 µm)