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Effective strategies for cancer therapy predicted by mathematical models. Cancer cells (red-crossed) and normal cells (blue circles) cohabit a tissue ecosystem. A Reducing the capacity of the tissue to carry cancer cells, e.g. with antiangiogenic therapy. B Weakening cancer defence mechanisms against host activities, e.g. immunotherapy. C Preventing cancer cells from generating a harsh environment for the host cells, e.g. influencing the microenvironment
