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. 2022 Jan 14;40(4):989–1033. doi: 10.1007/s10555-021-10006-2

Fig. 4.

Fig. 4

Metabolic characterization in vivo, in patients’ tumors, and experimental studies. Tumor diagnostic methods: clinical image analysis (PET-CT, MRI), tumor biopsy methods including histological and molecular genetic examinations (pathomorphological, immune, and next-generation sequencing–based phenotyping, and genetic analyses) are shown on the left side of the figure. Additionally, several in vitro and in vivo model systems and experimental studies using cell lines or patient-derived cells are shown on the right side of the figure