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. 2022 Jan 14;40(4):989–1033. doi: 10.1007/s10555-021-10006-2

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© The Author(s) 2021

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Fig. 6 — mTOR as a metabolic crossroad in the signaling network (simplified figures). a mTOR kinase and the mTORC1 and C2 complexes are metabolic and “cell-state” sensors in the signaling network. b The effector mechanisms and targets of mTORC1 and C2 complexes and their cellular regulatory functions. The activating (black) and inhibiting (red) effects are shown in the schematic diagram.