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. 2022 Feb 9;40(12):1904–1912. doi: 10.1016/j.vaccine.2021.12.072

Table 2.

COVID-19 vaccine side effects by manufacturer.

All Participants
N = 6966
Pfizer
N = 3486
Moderna
N = 2857
J&J
N = 623
Side Effects (n) 6966 3486 2857 623
 Fever 2084 (29.9) 770 (22.1) 1119 (39.2) 195 (31.3)
 Swollen lymph nodes 788 (11.3) 392 (11.2) 353 (12.4) 43 (6.9)
 Diarrhea 69 (1.0) 37 (1.1) 27 (0.9) 5 (0.8)
 Nausea or vomiting 1099 (15.8) 466 (13.4) 525 (18.4) 108 (17.3)
 Chills 285 (4.1) 101 (2.9) 150 (5.3) 34 (5.5)
 Injection site reactions 5493 (78.9) 2695 (77.3) 2468 (86.4) 330 (53.0)
 Severe allergic reactions 39 (0.6) 14 (0.4) 17 (0.6) 8 (1.3)
 Fatigue 4897 (70.3) 2312 (66.3) 2222 (77.8) 363 (58.3)
 New or worsening joint pain 1505 (21.6) 614 (17.6) 767 (26.8) 124 (19.9)
 New or worsening muscle pain 2113 (30.3) 894 (25.6) 1043 (36.5) 176 (28.3)
 Headache 3416 (49.0) 1538 (44.1) 1595 (55.8) 283 (45.4)
 Dizziness 81 (1.2) 39 (1.1) 35 (1.2) 7 (1.1)
 Missing 0 0 0 0
No. of Side Effects (n) 6966 3486 2857 623
 Mean (SD) 3.1 (2.00) 2.8 (1.91) 3.6 (2.00) 2.7 (2.09)
 Median [IQR] 3 [2.0,5.0] 3 [1.0,4.0] 4 [2.0,5.0] 3 [1.0,4.0]
 Min - Max (0–9) (0–9) (0–9) (0–8)
 0 side-effects 529 (7.6) 279 (8.0) 131 (4.6) 119 (19.1)
 1 to 2 side-effects 2419 (34.7) 1443 (41.4) 789 (27.6) 187 (30.0)
 3 or more side-effects 4018 (57.7) 1764 (50.6) 1937 (67.8) 317 (50.9)
 Missing 0 0 0 0
Sought medical care for any side effects(n) 6473 3222 2737 514
 Yes 201 (3.1) 90 (2.8) 89 (3.3) 22 (4.3)
 Missing 493 264 120 109
Hospitalized post-vaccination(n) 6473 3222 2737 514
 Yes 17 (0.3) 10 (0.3) 4 (0.1) 3 (0.6)
 Missing 493 264 120 109
Trouble with self-care due to side effects (Yes/No) (n) 6473 3222 2737 514
 Yes 2030 (31.4) 853 (26.5) 1037 (37.9) 140 (27.2)
 Missing 493 264 120 109
Trouble with s self-care due to side effects (Categorical) (n) 6473 3222 2737 514
 Not at all 4443 (68.6) 2369 (73.5) 1700 (62.1) 374 (72.8)
 A little 1166 (18.0) 509 (15.8) 562 (20.5) 95 (18.5)
 Somewhat 478 (7.4) 200 (6.2) 251 (9.2) 27 (5.3)
 A lot 386 (6.0) 144 (4.5) 224 (8.2) 18 (3.5)
 Missing 493 264 120 109
Worked less due to side effects(n) 4648 2380 1910 358
 Yes 1646 (35.4) 721 (30.3) 813 (42.6) 112 (31.3)
 Missing 2318 1106 947 265

Note: For two-dose vaccine series, data include side effects reported after either first or booster dose. For those who report missing work due to side effects, it is unknown whether time off from work was sanctioned by their employer to facilitate getting vaccinated.