Table 3.
COVID-19 Vaccine side effects, self-care and effect on work, by first or second injection.
| First dose |
Second Dose |
J&J N = 623 |
|||
|---|---|---|---|---|---|
| Pfizer N = 3486 |
Moderna N = 2857 |
Pfizer N = 3486 |
Moderna N = 2857 |
||
| Side Effects(n) | 3486 | 2857 | 3486 | 2857 | 623 |
| Fever | 211 (6.1) | 280 (9.8) | 688 (19.7) | 1027 (35.9) | 195 (31.3) |
| Swollen lymph nodes | 160 (4.6) | 160 (5.6) | 332 (9.5) | 286 (10.0) | 43 (6.9) |
| Diarrhea | 17 (0.5) | 5 (0.2) | 20 (0.6) | 22 (0.8) | 5 (0.8) |
| Nausea or vomiting | 158 (4.5) | 167 (5.8) | 369 (10.6) | 449 (15.7) | 108 (17.3) |
| Chills | 20 (0.6) | 16 (0.6) | 81 (2.3) | 134 (4.7) | 34 (5.5) |
| Injection site reactions | 2418 (69.4) | 2245 (78.6) | 2289 (65.7) | 2180 (76.3) | 330 (53.0) |
| Severe allergic reactions | 5 (0.1) | 5 (0.2) | 13 (0.4) | 14 (0.5) | 8 (1.3) |
| Fatigue | 1309 (37.6) | 1194 (41.8) | 2051 (58.8) | 2060 (72.1) | 363 (58.3) |
| New or worsening joint pain | 219 (6.3) | 277 (9.7) | 532 (15.3) | 661 (23.1) | 124 (19.9) |
| New or worsening muscle pain | 333 (9.6) | 376 (13.2) | 756 (21.7) | 912 (31.9) | 176 (28.3) |
| Headache | 788 (22.6) | 751 (26.3) | 1278 (36.7) | 1407 (49.2) | 283 (45.4) |
| Dizziness | 13 (0.4) | 11 (0.4) | 26 (0.7) | 24 (0.8) | 7 (1.1) |
| Missing | 0 | 0 | 0 | 0 | 0 |
| No. of Side Effects (n) | 3486 | 2857 | 3486 | 2857 | 623 |
| Mean (SD) | 1.6 (1.39) | 1.9 (1.56) | 2.4 (1.92) | 3.2 (2.04) | 2.7 (2.09) |
| Median [IQR] | 1 [1.0,2.0] | 1 [1.0,3.0] | 2 [1.0,4.0] | 3 [2.0,5.0] | 3 [1.0,4.0] |
| Min - Max | (0–9) | (0–8) | (0–9) | (0–9) | (0–8) |
| 0 side-effects | 633 (18.2) | 350 (12.3) | 538 (15.4) | 240 (8.4) | 119 (19.1) |
| 1 to 2 side-effects | 2120 (60.8) | 1725 (60.4) | 1489 (42.7) | 911 (31.9) | 187 (30.0) |
| More than 3 side-effects | 733 (21.0) | 782 (27.4) | 1459 (41.9) | 1706 (59.7) | 317 (50.9) |
| Missing | 0 | 0 | 0 | 0 | 0 |
| Sought Medical care for any side effects(n) | 2884 | 2525 | 2964 | 2622 | 514 |
| Yes | 41 (1.4) | 45 (1.8) | 68 (2.3) | 50 (1.9) | 22 (4.3) |
| Missing | 602 | 332 | 522 | 235 | 109 |
| Hospitalized post-vaccination(n) | 2884 | 2525 | 2964 | 2622 | 514 |
| Yes | 6 (0.2) | 1 (0.0) | 9 (0.3) | 3 (0.1) | 3 (0.6) |
| Missing | 602 | 332 | 522 | 235 | 109 |
| Trouble with self-care due to side effects (Yes/No) (n) | 2884 | 2525 | 2964 | 2622 | 514 |
| Yes | 337 (11.7) | 430 (17.0) | 764 (25.8) | 943 (36.0) | 140 (27.2) |
| Missing | 602 | 332 | 522 | 235 | 109 |
| Trouble with self-care due to side effects (Categorical) (n) | 2884 | 2525 | 2964 | 2622 | 514 |
| Not at all | 2547 (88.3) | 2095 (83.0) | 2200 (74.2) | 1679 (64.0) | 374 (72.8) |
| A little | 260 (9.0) | 306 (12.1) | 453 (15.3) | 520 (19.8) | 95 (18.5) |
| Somewhat | 54 (1.9) | 80 (3.2) | 181 (6.1) | 220 (8.4) | 27 (5.3) |
| A lot | 23 (0.8) | 44 (1.7) | 130 (4.4) | 203 (7.7) | 18 (3.5) |
| Missing | 602 | 332 | 522 | 235 | 109 |
| Missed work or worked less due to side effects(n) | 2141 | 1781 | 2147 | 1764 | 358 |
| Yes | 239 (11.2) | 229 (12.9) | 628 (29.3) | 743 (42.1) | 112 (31.3) |
| Missing | 1345 | 1076 | 1339 | 1093 | 265 |
| Days worked less (n) | 180 | 162 | 443 | 504 | 79 |
| Mean (SD) | 2.3 (3.76) | 2.5 (5.24) | 2.4 (6.48) | 1.8 (2.99) | 2.3 (2.88) |
| Median (IQR) | 1 [1.0,2.0] | 1 [1.0,2.0] | 1 [1.0,2.0] | 1 [1.0,2.0] | 1 [1.0,3.0] |
| Min-Max | (1–35) | (1–60) | (1–90) | (1–60) | (1–21) |
| 1 day | 105 (3.0) | 82 (2.9) | 277 (7.9) | 328 (11.5) | 43 (6.9) |
| 2 days | 37 (1.1) | 47 (1.6) | 102 (2.9) | 103 (3.6) | 16 (2.6) |
| 3 or more days | 38 (1.1) | 33 (1.2) | 64 (1.8) | 73 (2.6) | 20 (3.2) |
| Missing | 3306 | 2695 | 3043 | 2353 | 544 |
| Days missed work (n) | 165 | 176 | 478 | 592 | 99 |
| Mean (SD) | 1.9 (2.97) | 2.3 (5.25) | 1.9 (5.52) | 1.6 (2.63) | 1.7 (1.92) |
| Median (IQR) | 1 [1.0,2.0] | 1 [1.0,2.0] | 1 [1.0,2.0] | 1 [1.0,2.0] | 1 [1.0,2.0] |
| Min-Max | (1–34) | (1–60) | (1–100) | (1–60) | (1–16) |
| 1 day | 109 (3.1) | 104 (3.6) | 331 (9.5) | 425 (14.9) | 66 (10.6) |
| 2 days | 34 (1.0) | 48 (1.7) | 101 (2.9) | 117 (4.1) | 21 (3.4) |
| 3 or more days | 22 (0.6) | 24 (0.8) | 46 (1.3) | 50 (1.8) | 12 (1.9) |
| Missing | 3321 | 2681 | 3008 | 2265 | 524 |