Table 1.
Quality of evidence for moderate-to-severe OHSS.
| Comparison | Indirect evidence | Direct evidence | Network meta-analysis | |
|---|---|---|---|---|
| Certainty of evidence | Certainty of evidence | RR(95%CI) | Certainty of evidence | |
| Aspirin: Placebo/blank | Moderate(risk of bias) | Moderate(risk of bias) | 0.83 (0.21, 2.95) | Low(risk of bias, imprecision) |
| Aspirin: Letrozole | Moderate(risk of bias) | High | 2.52 (0.7, 9.69) | High |
| Aspirin: Cabergoline | Low(risk of bias, publication bias) | NA | 1.67 (0.38, 6.55) | Low(risk of bias, publication bias) |
| Aspirin: Albumin | Moderate(risk of bias) | NA | 1.39 (0.32, 6.3) | Moderate(risk of bias) |
| Aspirin: HES | Moderate(risk of bias) | NA | 3.22 (0.55, 18.87) | Moderate(risk of bias) |
| Aspirin: Metformin | Moderate(risk of bias) | NA | 1.4 (0.27, 6.97) | Moderate(risk of bias) |
| Aspirin: Calcium | Moderate(risk of bias) | NA | 5.14 (0.86, 30.1) | Moderate(risk of bias) |
| Aspirin: Glucocorticoids | Moderate(risk of bias) | NA | 0.83 (0.14, 4.32) | Low(risk of bias, imprecision) |
| Aspirin: Quinagolide | Moderate(risk of bias) | NA | 1.79 (0.28, 10.41) | Moderate(risk of bias) |
| Letrozole: Placebo | Moderate(publication bias) | Moderate(risk of bias) | 0.33 (0.07, 1.26) | Moderate(publication bias) |
| Letrozole: Cabergoline | Moderate(publication bias) | NA | 0.66 (0.13, 2.81) | Moderate(publication bias) |
| Letrozole: Albumin | High | High | 0.55 (0.11, 2.62) | High |
| Letrozole: HES | High | High | 1.28 (0.19, 8.08) | High |
| Letrozole: Metformin | Moderate(risk of bias) | NA | 0.56 (0.09, 2.85) | Moderate(risk of bias) |
| Letrozole: Calcium | Moderate(risk of bias) | NA | 2.03 (0.3, 12.97) | Moderate(risk of bias) |
| Letrozole: Glucocorticoids | Moderate(risk of bias) | NA | 0.33 (0.05, 1.82) | Moderate(risk of bias) |
| Letrozole: Quinagolide | Moderate(risk of bias) | NA | 0.7 (0.1, 4.27) | Moderate(risk of bias) |
| Cabergoline: Placebo | Moderate(risk of bias) | Low(risk of bias, publication bias) | 0.5 (0.3, 0.83) | Moderate(risk of bias) |
| Cabergoline: Albumin | High | Moderate(publication bias) | 0.84 (0.42, 1.92) | Moderate(imprecision) |
| Cabergoline: HES | Low(risk of bias, publication bias) | High | 1.94 (0.61, 6.85) | High |
| Cabergoline: Metformin | Low(risk of bias, publication bias) | NA | 0.85 (0.29, 2.59) | Very low(risk of bias, publication bias, imprecision) |
| Cabergoline: Calcium | Low(risk of bias, publication bias) | Moderate(risk of bias) | 3.09 (1.01, 10.13) | Moderate(risk of bias) |
| Cabergoline: Glucocorticoids | Low(risk of bias, publication bias) | High | 0.5 (0.16, 1.56) | High |
| Cabergoline: Quinagolide | Low(risk of bias, publication bias) | High | 1.08 (0.32, 3.64) | Moderate(imprecision) |
| Albumin: Placebo | Low(risk of bias, publication bias) | Moderate(publication bias) | 0.6 (0.28, 1.08) | Moderate(publication bias) |
| Albumin: HES | Moderate(publication bias) | High | 2.32 (0.69, 7.63) | High |
| Albumin: Metformin | Moderate(publication bias) | NA | 1.02 (0.31, 3.05) | Low(publication bias, imprecision) |
| Albumin: Calcium | Moderate(publication bias) | NA | 3.69 (0.94, 13.67) | Moderate(publication bias) |
| Albumin: Glucocorticoids | Moderate(publication bias) | NA | 0.6 (0.15, 1.97) | Moderate(publication bias) |
| Albumin: Quinagolide | Moderate(publication bias) | NA | 1.29 (0.31, 4.75) | Moderate(publication bias) |
| HES: Placebo | Moderate(publication bias) | High | 0.26 (0.08, 0.77) | High |
| HES: Metformin | High | NA | 0.44 (0.09, 1.87) | High |
| HES: Calcium | Moderate(risk of bias) | NA | 1.58 (0.31, 8.05) | Moderate(risk of bias) |
| HES: Glucocorticoids | High | NA | 0.26 (0.05, 1.19) | High |
| HES: Quinagolide | High | NA | 0.55 (0.1, 2.75) | High |
| Metformin: Placebo | NA | High | 0.59 (0.22, 1.49) | High |
| Metformin: Calcium | High | NA | 3.63 (0.79, 17.08) | High |
| Metformin: Glucocorticoids | High | NA | 0.59 (0.14, 2.39) | High |
| Metformin: Quinagolide | High | NA | 1.27 (0.26, 5.79) | High |
| Calcium: Placebo | Low(risk of bias, publication bias) | High | 0.16 (0.05, 0.52) | High |
| Calcium: Glucocorticoids | Moderate(risk of bias) | NA | 0.16 (0.03, 0.77) | Moderate(risk of bias) |
| Calcium: Quinagolide | Moderate(risk of bias) | NA | 0.35 (0.06, 1.74) | Moderate(risk of bias) |
| Glucocorticoids: Placebo | Low(risk of bias, publication bias) | High | 0.99 (0.35, 2.91) | Moderate(imprecision) |
| Glucocorticoids : Quinagolide | High | NA | 2.15 (0.43, 10.88) | High |
| Quinagolide: Placebo | Low(risk of bias, publication bias) | High | 0.46 (0.14, 1.56) | High |
NA, Not Applicable.