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. 2022 Jan 26;11:739628. doi: 10.3389/fcimb.2021.739628

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Copyright © 2022 Alfandari, Ben Ami Pilo, Abou Karam, Dagan, Joubran, Rotkopf, Regev-Rudzki and Porat

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kinetic measurement of Pf-derived EV uptake into either monocytes or macrophages using IFC. Pf-derived EVs were labeled by Thiazole orange (TO), and their uptake into monocytes (THP-1 cells) or macrophages (differentiated from THP-1 cells) was measured for 1 hour. Graph representing the signal modification in TO intensity that was detected over time originating from monocytes and macrophages recipient cells. Graph representing at least three independent biological replicates. Cell types were compared with a linear mixed effects model, with cell type and time as fixed factors, and sample ID as a random factor. Statistics were done in R, v. 4.0.4, using the package ‘lmerTest’. Grey area around the lines represents 95% confidence intervals, p<0.001.