Table 2.
Enriched metabolite sets in frailty phenotype.
| Frailty phenotype | Metabolite set | Match status | Fold change | Metabolites | Raw p | |
|---|---|---|---|---|---|---|
| Up-regulated | Down-regulated | |||||
| Frailty | Glycolysis | 1/1 | 56.5 | Pyruvic acid | – | 0.0177 |
| Pyruvaldehyde degradation | 1/1 | 56.5 | Pyruvic acid | – | 0.0177 | |
| Glycine and serine metabolism | 2/16 | 7.07 | Pyruvic acid | Glyceric acid | 0.0190 | |
| Glycerolipid metabolism | 1/2 | 28.25 | – | Glyceric acid | 0.0352 | |
| Slowness | Inositol metabolism | 1/1 | 56.5 | D-Glucuronic acid | – | 0.0177 |
| Starch and sucrose metabolism | 1/1 | 56.5 | D-Glucuronic acid | – | 0.0177 | |
| Glycerolipid metabolism | 1/2 | 28.25 | – | Glyceric acid | 0.0352 | |
| Inactivity | Fatty acid metabolism | 3/3 | 10.27 | L-Carnitine, Palmitic acid, L-Palmitoylcarnitine |
– | 0.0007 |
| Mitochondrial beta-oxidation of long chain saturated fatty acids | 2/2 | 10.26 | L-Carnitine, Stearoylcarnitine |
– | 0.0087 | |
| Fatigue | Vitamin B6 metabolism | 1/1 | 37.74 | – | 4-Pyridoxic acid | 0.0265 |
| Shrink | Transfer of acetyl groups into mitochondria | 2/5 | 7.555 | Citric acid | Oxalacetic acid | 0.0220 |