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. 2022 Jan;11(1):245–257. doi: 10.21037/gs-21-908

Figure 7.

Figure 7

BMP1 could mediate the activity and expression of LOX in ATC cells. (A) The expression of BMP1 was knocked down using si-RNAs in 8505C cells. (B) The expression level of LOX in 8505C cells after si-BMP1 transfection was measured by Western blot and quantitative real-time PCR. (C) The activity of LOX was downregulated after knocking down BMP1 in 8505C cells. (D) The activity of LOX was determined after BMP1 overexpression and treatment with BAPN in 8505C cells. *, P<0.05; **, P<0.01. BMP-1, bone morphogenetic protein-1; si-RNAs, short interfering RNAs; LOX, Lysyl oxidase; BAPN, beta-aminopropionitrile (LOX inhibitor).