Figure 5.
Exosomes loaded with RBP-J decoy oligodeoxynucleotides (ODNs) attenuated liver inflammation in mice with CCl4-induced fibrosis. (A) Schematic illustration of the procedure used for the loading of exosomes with RBP-J decoy ODNs to treat liver fibrosis in mice. (B) Liver sections were subjected to hematoxylin and eosin (H&E) staining. The micrographs in the lower row are a higher magnification of the yellow frames in the upper row. (C) Serum albumin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in the mice. (D) The mRNA levels of IL1β, IL6, TNF-α, PDGF-B, and TGFβ in the liver were determined by qRT-PCR. Bars = means ± SD; * P < 0.05, ** P < 0.01, *** P < 0.001.