Figure 1.

Schematic illustration of cell origin for making human islet organoids. (A-C) Many different strategies have been used to generate pancreatic endocrinal cell types, including islet lineage cells differentiated from human PSCs, islet cells and pancreatic progenitors derived from human pancreas, human β cell line and islet-like cells by trans-differentiation from non-islet lineage cells. (D) Accessory cells are proved to promote generation and vascularization of human islet organoids after long term culture or transplantation.