Figure 7.

Evaluation of treatment efficacy of SHIFT&DOX in rabbit orthotopic HCC models. (A) Schematic of VX2 orthotopic models and treatments. (B) Verification of VX2 orthotopic models via MRI and DSA-guided embolization of SHIFT&DOX as well as CT-monitored embolic evaluation. (C) Representative MRI images. (D) Representative histological staining of resected tumor lesions after 10 days embolization. (E) Representative fluorescence images of DOX in resected tumor tissues. (F) Quantitative analysis of tumor volume. (G, H) Quantitative analysis of Ki-67 and TUNEL positive rate in tumor specimen after 10 days in tumors. Data represent mean ± SD, n = 3. * p < 0.05; ** p < 0.01; *** p < 0.001, **** p < 0.0001, one-way ANOVA test.