Fig 10.

Proposed tanycyte-POMC neuron communication under normal conditions and under GKRP silencing. Under endogenous conditions, tanycytes sense hypoglycemia by producing βHB that reduces the activity of POMC neurons, contributing to the generation of hunger. After refeeding, ketogenesis stops and tanycytes incorporate glucose and generate satiety signals, such as lactate, which increases the excitability of POMC neurons. In contrast, the loss of GKRP function impacts a higher lactate production in fasting, especially after a meal, which exacerbates satiety.