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Schematic representation of the most important molecular mechanisms and signaling pathways of andrographolide in central nervous system disorders. ↑: increase; ↓: decrease; ANDRO: andrographolide; ROS: reactive oxidative species; NO: nitric oxide; iNOS: inducible nitric oxide; IL: interleukins; TNF: tumor necrosis alpha; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells. ATG 13 autophagy-related protein 13, ULK ½ Unc-51 like autophagy activating kinase.
