Table 1. Evaluation of esophageal motility with FLIP Panometry.

The contractile response to distension was based on evaluation of the FLIP study protocol including from the 50ml to 70ml fill volume. Esophagogastric junction (EGJ) opening applied the EGJ-distensibility index (DI) from the 60ml FLIP fill volume and the maximum EGJ diameter from the 60ml or 70ml FLIP fill volume.

FLIP Panometry Contractile Response Patterns	Definition
Normal Contractile Response NCR	Repetitive Antegrade Contraction (RACs), defined by the RAC Rule of 6s (Ro6s): • ≥6 consecutive antegrade contractions of • ≥6 cm in axial length occurring at • 6+/−3 antegrade contractions per minute regular rate
Borderline Contractile Response BCR	• Not meeting RAC Ro6s • Distinct antegrade contractions of at least 6-cm axial length present • Not SRCR
Impaired/Disordered Contractile Response IDCR	• No distinct antegrade contractions • May have sporadic or chaotic contractions not meeting antegrade contractions • Not SRCR
Absent Contractile Response ACR	• No contractile activity in the esophageal body
Spastic-Reactive Contractile Response SRCR	• Presence of any of the following features:  • Sustained occluding contractions or  • Sustained lower esophageal sphincter (LES) contractions or  • Repetitive retrograde contractions (RRCs), defined by at least 6 consecutive retrograde contractions occurring at a rate of > 9 contractions per minute
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FLIP Panometry EGJ opening classification
Reduced EGJ opening (REO)	• EGJ-DI <2.0 mm2/mmHg AND • Maximum EGJ diameter <12mm
Borderline-reduced EGJ opening (BrEO)	• EGJ-DI <2.0 mm2/mmHg OR • Maximum EGJ diameter <14 mm, • but not REO
Borderline-normal EGJ opening (BnEO)	• Maximum EGJ diameter 14–16 mm OR • EGJ-DI <2.0 mm2/mmHg and maximum EGJ diameter ≥16mm
Normal EGJ opening (NEO)	• EGJ-DI ≥2.0 mm2/mmHg AND • Maximum EGJ diameter ≥16mm