Table 1.

Framework of intervention research domains and general clinical questions.

Clinical Question
Formative Research on the Intervention
Why does [health problem] occur in CMC?
What is the pathogenesis of [health problem]?
What is the prevalence of [health problem]?
What are the risk factors for [health problem]?
How does the severity of [health problem] change over time?
Design of the Intervention
What can be done to prevent/mitigate [health problem]?
What is the best user-centered design for [intervention] to address [problem]?
How patient/family centered is [intervention]?
How feasible is [intervention]?
Clinical Effectiveness of the Intervention
How clinically effective is [intervention] for [problem]?
How much does [intervention] improve health / functioning / quality of life?
How well does [intervention] prevent [disease/outcome]?
Is [intervention A] more clinically effective than [intervention B]?
How safe, equitable, and timely is [intervention]?
Value of the Intervention
How cost effective is [intervention]?
Is [intervention A] more cost effective than [intervention B]?
Implementation, Scale, and Spread of the Intervention
What are the barriers and facilitators of implementing [intervention]?
How much variation in [intervention] exists in clinical practice?
What’s the best way to implement [intervention]?
What’s the best way to decide whether to use/undergo [intervention]?
What’s the best way to sustain use of [intervention]?
What’s the best way to pay for [intervention]?
What policies best enable use of [intervention]?