Skip to main content
. Author manuscript; available in PMC: 2023 Feb 7.
Published in final edited form as: Curr Biol. 2021 Dec 21;32(3):586–599.e7. doi: 10.1016/j.cub.2021.12.006

Figure 7. Serotonin neuron inhibition disrupts meta-learning.

Figure 7.

(A) Schematic of experiment to reversibly inactivate serotonin neurons and representative expression of hM4Di-mCherry in dorsal raphe serotonin neurons.

(B) Schematic of simulated lesion in which models were fit to mouse behavior from vehicle sessions and then meta-learning variables (i.e., ε and v) were set to zero.

(C) Simulated behavior with meta-learning intact, fit to vehicle behavior (left) and simulated lesion (right).

(D) Mouse behavior with vehicle injections (control experiment) and drug (agonist 21). Lines are mean choice probability and shading is Bernoulli SEM.

(E) Exponential time constants for transitions from simulated behavior and simulated lesions.

(F) Time constants from mice (with 95% CI). (G) Simulated behavior from mice expressing mCherry in serotonin neurons with vehicle (left) and agonist 21 (right) injections.

(H) Mouse behavior with vehicle injections and drug (agonist 21).

(I) Simulation time constants from fluorophore-control mice.

(J) Time constants from fluorophore-control mice (with 95% CI).

See also Figure S6.