TABLE 1.

Key pathways and the major DEGs in these pathways related to inflammation

Pathway	Key DEGs from the pathway
	IL vs. AIL	IL vs. PIL	IL vs. BIL
PI3K‐Akt signaling pathway	TLR2, NFKB1, PI3KCG, F2R	TLR2, SYK, JAK1, PIK3CG, PIK3CA_B_D, AKT, NFKB1, RAF1	TLR2, SYK, JAK1, PIK3CG, PIK3CA_B_D, AKT, ERK, NFKB1, RAF1,
JAK‐STAT signaling pathway	STAT1, IL−2, SOCS1, AOX	JAK1, STAT1, AKT, SOCS1, AOX, IL−2, RAF1	IL−2, JAK1, STAT1, AKT, AOX, SOCS1, RAF1
NF‐κB signaling pathway	IL−1B, IL−1R1, CD14, VCAM1, NFKB1, IRAK1, CCL21	IL−1R1, IL−1B, SYK, CD14, TLR4, NFKB1, CCL4, CXCL2, CCL21, COX2(PTGS2), IRAK1	IL−1R1, IL−1B, CD14, TLR4, SYK, NFKB1, COX2, CCL4, CXCL2, CCL21, IRAK1
MAPK signaling pathway	NFKB1, IL−1R1, CD14, MAP3K6, IRAK1	NFKB1, JNK, AKT, IL−1A, IL−1R1, IRAK1, CD14, RAF1, MAP3K6, MAP3K5, MAP2K7	CD14, IL−1A, IL−1R1, IRAK1, HRAS, RAF1, ERK, NFKB1, AKT, MAP3K6, MAP3K5, MAP3K1, MAP2K7, JNK