Fig. 2. Parameterization and evaluation of SMAP performance using a simulation study.
(a) Diagram showing the simulation procedure. See Supplementary Fig. 4 for a more detailed procedure. “H” is used to denote heterozygote. (b) Curve plot showing Cscore distribution. The X-axis represents 420 samples and the y-axis represents Cscore between a testing sample and each sample in the simulation data. (c) Score distribution of the matched sample with the highest Cscore and “true” sample along with the percentage of samples being shuffled. The X-axis represents the percentage of samples being shuffled and the Y-axis denotes Cscore. The red dot is the “true” sample and the blue is the one with the highest score. (d) A zoom-in plot of the score distribution with samples being shuffled from 70% to 100%. Smoothing curves based on linear model separately for each group are shown in red and blue, respectively, with 95% confidence intervals in grey.