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. 2022 Feb 8;12:2067. doi: 10.1038/s41598-022-06118-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mutation and deletion efficiencies of fetuses harvested from in vitro transcribed (IVT) and synthetic gRNA edited embryo transfers. (a) Mutation rates and (b) deletion rates in fetuses edited with Cas9 protein and either IVT or synthetic gRNAs btHP 5′g2 and btHP 3′g2. A fetus was considered mutated if a mutation was detected at one or both target sites. (c) Frequency of types of deletions detected in edited fetuses. Mono = monoallelic (orange); Bi = biallelic (aqua), Mosaic (purple). Error bars = SEM.