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. 2022 Feb 8;13(2):124. doi: 10.1038/s41419-022-04550-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Amplification alteration of the APEX1 gene in thyroid cancer and normal tissue samples from The Cancer Genome Atlas (TCGA) database. B Real-time PCR detection of the mRNA expression level of Ref-1 in tumor and normal tissue samples from 16 patients. C Western blot detection of the protein expression level of Ref-1 in tumor and normal tissue specimens from 8 patients. D Representative immunohistochemical staining for Ref-1 in PTC specimens. E Percentages of samples with different BRAF mutation statuses and specific Ref-1 expression levels among 178 PTC cases. F RFS analysis of groups based on the high and low expression of Ref-1 among 178 PTC cases. *P < 0.05, **P < 0.01.