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. 2022 Feb 8;13(2):124. doi: 10.1038/s41419-022-04550-0

Fig. 4. E3330 enhanced the proapoptotic capacity of vemurafenib in BCPAP and K-1 cells.

Fig. 4

A, B The cell apoptosis rate measured by flow cytometric analysis in BCPAP and K-1 cell lines. C, D The mitochondrial membrane potential evaluation by detecting JC-1 content in BCPAP and K-1 cell lines. E, F Mitochondrial apoptosis pathway-associated protein expression detection by western blot assay in BCPAP and K-1 cell lines. BCPAP and K-1 cell lines were pretreated with DMSO, vemurafenib (10 μM), E3330 (50 μM), and combination (10 μM vemurafenib + 50 μM E3330), respectively. *P < 0.05, **P < 0.01, ***P < 0.001.