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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Leukoc Biol. 2021 Aug 9;111(3):667–693. doi: 10.1002/JLB.6A1120-744R

Figure 11: Gene Expression Profile Comparison of Polarized MΦ Phenotypes Identifies Unique and Overlapping Immunomodulatory Functions between 24- and 72-hour Polarization Times.

Figure 11:

Gene Ontology (GO) annotation of global myeloid gene expression identifies the differential biological functionality between the 24 (light colored bars) and 72-hour (dark colored bars) time points in five MΦ phenotypes. For each MΦ phenotype, the top 15 impacted GO processes significantly enriched (p < 0.05) for both time points were plotted as such: M1 MΦs (IFN-γ/LPS treated, shown in red) (A), M2a MΦs (IL-4/IL-13 treated, shown in yellow) (B), M2b MΦs (IC/LPS treated, shown in green) (C), M2c MΦs (IL-10 treated, shown in gray) (D), and M2d MΦs (IL-6/LIF treated, shown in purple) (E). GO process annotation was based on three experimental replicates for each MΦ s phenotype (N=3).