Figure 12: Metabotype Profiling of Polarized MΦs at 24 and 72 Hours.
Pathway impact scores derived from pathway topology analysis were compared at 24 and 72 hours for the M1 MΦs (IFN-γ/LPS treated, shown in red) (A), M2a MΦs (IL-4/IL-13 treated, shown in yellow) (B), M2b MΦs (IC/LPS treated, shown in green) (C), M2c MΦs (IL-10 treated, shown in gray) (D), and M2d MΦs (IL-6/LIF treated, shown in purple) (E). The top 15 enriched pathways are depicted in each spider plot with the hatched plots and solid plots representing the 24- and 72-hour time points, respectively.