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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Leukoc Biol. 2021 Aug 9;111(3):667–693. doi: 10.1002/JLB.6A1120-744R

Figure 4: Gene Expression Profile Comparison of Polarized MΦ Phenotypes Identifies Unique and Overlapping Immunomodulatory Functions.

Figure 4:

Gene Ontology (GO) annotation of global myeloid gene expression in five MΦ phenotypes identifies relative biological functionality across polarized states. Multiplexed myeloid gene expression profile of all five polarized MΦ phenotypes was used to annotate impacted biological functionality based on GO Processes. For each MΦ phenotype, the top 15 impacted GO processes significantly enriched (p < 0.05) were plotted relative to the other four polarized MΦ phenotypes. Enrichment plots for prioritized GO process profile include all five polarized MΦ phenotypes: M1 MΦs (IFN-γ/LPS treated, shown in red) (A), M2a MΦs (IL-4/IL-13 treated, shown in yellow) (B), M2b MΦs (IC/LPS treated, shown in green) (C), M2c MΦs (IL-10 treated, shown in gray) (D), and M2d MΦs (IL-6/LIF treated, shown in purple) (E). GO process annotation was based on three experimental replicates for each MΦ phenotype (N=3).