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. 2022 Feb 8;9:8. doi: 10.1186/s40580-022-00299-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Simulation of a gut-on-a-chip under various fluidic flows and geometric conditions. A Wall shear stress is calculated with respect to the height of the microchannel. B Wall shear stress is calculated with respect to the width of the microchannel. C Wall shear stress is calculated with respect to the distance between the micropillars. D Flow speed distribution in the cell culture microchannel. CFD simulations were performed to analyze the velocity at various concentrations of 0.18 M, 0.36 M, 0.72 M PEG solutions. E Velocity distribution inside the microchannel is calculated in a section of A–D