| Morphology |
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| 1) Normal |
Mucosal pattern (MP): circular |
Type A: round/oval pits with regular microvasculature (MW) |
MP: regular |
MP: circular, ridged/villous, or tubular |
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Vascular pattern (VP): normal |
VP: regular |
VP: blood vessels situated regularly along or between mucosa ridges and/or those showing normal, long, branching patterns |
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Abnormal blood vessels (ABV): absent |
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| 2) Intestinal metaplasia |
MP: ridged/villous |
Type B: villous/ridge/linear pits with regular MW |
MP-regular |
Not tested |
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VP: normal |
Type C: absent pits with regular MW |
VP-regular (villous/gyrus) |
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ABV: absent |
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| 3) Dysplasia |
MP: irregular/distorted |
Type D: distorted pits with irregular MW |
MP-irregular |
MP: absent or irregular patterns |
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VP: abnormal |
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VP: irregular |
VP: focally or diffusely distributed vessels not following normal architecture of the mucosa |
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ABV: present |
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| Performance of various classifications |
Sensitivity, specificity, & Positive predictive value (PPV) of ridge/villous pattern for diagnosis of intestinal metaplasia (IM) without high grade dysplasia (HGD) were 93.5%, 86.7%, and 94.7%, respectively |
87.9% in magnification endoscopy corresponded to histological diagnosis |
The magnified NBI images had a sensitivity of 94%, a specificity of 76%, a PPV of 64%, and a NPV of 98% for HGIN |
High confidence |
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The sensitivity, specificity, and PPV of irregular/distorted pattern for HGD were 100%, 98.7%, and 95.3%, respectively |
PPV & negative predictive value (NPV) for type A (Columnar mucosa without IM) was 100% & 97% respectively |
No data on observer agreement |
predictions by the experts yielded high accuracy |
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For Type B & C (IM) was 88% and 91% respectively |
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sensitivity, and specificity (92%, 91%, and 93% respectively) |
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For Type D (high grade dysplasia) was 81 & 99% |
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Inter-observer agreement was substantial (k=0.681) |
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Inter and Intraobserver agreement was Kappa of 0.71–0.87 (Nonexperts) and 0.78–0.91(Experts) |
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