Table 6. NBI International Colorectal Endoscopic (NICE) Classification (50,51).

	Type 1	Type 2	Type 3
Color	Same or lighter than background	Browner relative to background	Brown to dark brown relative to background; sometimes patchy whiter areas
Vessels	None, or isolated lacy vessels coursing across the lesion	Brown vessels surrounding white structures	Has areas of disrupted or missing vessels
Surface pattern	Dark or white spots of uniform size, or homogeneous absence of pattern	Oval, tubular or branched white structure surrounded by brown vessels.	Amorphous or absent surface pattern
Most likely pathology	Hyperplastic	Adenoma (Figure 5)	Deep submucosal invasive cancer

Type 2 consists of Vienna classification types 3, 4 & superficial 5 (all adenomas with either low or high grade dysplasia or with superficial submucosal carcinoma). The presence of HGD or superficial submucosal carcinoma may be suggested by an irregular vessel or surface pattern, and is often associated with atypical morphology.