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. 2022 Jan 26;12:764247. doi: 10.3389/fphar.2021.764247

FIGURE 1.

FIGURE 1

The effect of SHI on sepsis-induced ALI. The mice were intragastrically treated with drugs 2 h before the surgery, and at 0, 2, 12 h after the CLP surgery. (A) The survival percentage of sepsis mice. (B) The histopathological alteration by H&E staining. The green arrows indicate the infiltration of inflammatory cells. (C,D) ECM1 expression in the lung tissues by immunohistochemistry staining. (E) The wet/dry ratio of the lungs. (F) The BALF relative protein levels. (G) The lung MPO activity. The serum relative levels of (H) TNF-α, (I) IL-6, (J) IL-1β, (K) GM-CSF, (L) IL-10, and (M) TGF-β. The data are expressed as mean ± SD. Compared with sham: # p < 0.05, ## p < 0.01. Compared with CLP: *p < 0.05, **p < 0.01.