Figure 2.

Piezo1 is involved in various pathological chronic inflammation processes and acts as a sensor and effector of mechanical stress within tissues in inflammation. Chronic inflammation is characterized by tissue injury, inflammatory infiltration, and proliferative repair. The Piezo1 channel transduces mechanical forces into intracellular inflammatory signals to induce injury and inflammation, and the development of inflammation alters the mechanical properties of tissues. Piezo1 senses changes in mechanical stress in the local environment and regulates the progression of chronic inflammation.