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. 2022 Jan 26;13:816149. doi: 10.3389/fimmu.2022.816149

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Copyright © 2022 Liu, Hu, Zheng, Feng, Zhan, Wang, Xu and Hua

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the role of Piezo1 in atherosclerosis. Piezo1 on vascular endothelial cells senses the shearing force of blood flow, and laminar flow produces NO through Piezo1, which has the effect of protecting vascular endothelium. Disturbed blood flow shear force activates Piezo1, activates inflammatory pathways through integrin activation and PI3K-related signaling pathways to cause vascular endothelial inflammation, reduces eNOS activation, and induces monocytes to accumulate to the injured site, accelerating the formation of atherosclerotic plaques.