. 2021 Nov;50(11):2161–2171. doi: 10.18502/ijph.v50i11.7570

Table 1:

Characteristics of included studies

*Author, Year*	*Group*	*Sample size*	*Intervention*	*Duration (week)*	*Mean age (year)*	*Mean course of disease (year)*	*FBG (mmol/L)*	*Dosage*	*Administration route*
An 2018(4)	T	16	Mecobalamin + mosapride	4	73.1±8.2	4.5±1.6	-	0.5mg tid	Po
	T	16	Mecobalamin + mosapride	4	73.1±8.2	4.5±1.6	-	5mg tid	Po
	C	16	Mosapride		72.8±8.0	4.7±2.0	-	5mg tid	Po
Du 2015(5)	T	50	Mecobalamin + domperidone	4	58.3±5.9	-	-	0.5mg tid	Po
	T	50	Mecobalamin + domperidone	4	58.3±5.9	-	-	10mg tid	Po
	C	50	Domperidone		59.1±5.8	-	-	10mg tid	Po
Gu 2015(6)	T	34	Mecobalamin + mosapride	8	70.1±6.9	3.7±0.9	6.8±1.0	0.5mg tid	Po
	T	34	Mecobalamin + mosapride	8	70.1±6.9	3.7±0.9	6.8±1.0	5mg tid	Po
	C	36	Mosapride		69.8±6.9	3.8±0.8	6.8±0.9	5mg tid	Po
Guan 2013(7)	T	41	Mecobalamin + mosapride	4	-	-	-	0.5mg qd	Im
	T	41	Mecobalamin + mosapride	4	-	-	-	5mg tid	Po
	C	44	Mosapride		-	-	-	5mg tid	Po
Guo 2017(8)	T	50	Mecobalamin + domperidone	4	51.7±3.6	-	-	0.5mg tid	Po
	T	50	Mecobalamin + domperidone	4	51.7±3.6	-	-	10mg tid	Po
	C	50	Domperidone		52.1±3.5	-	-	10mg tid	Po
Huang 2012(9)	T	34	Mecobalamin+ mosapride	4	46.8±10.9	10.2±6.8	-	0.5mg tid	Po
	T	34	Mecobalamin+ mosapride	4	46.8±10.9	10.2±6.8	-	10mg tid	Po
	C	36	Mosapride		47.1±10.5	10.5±6.9	-	10mg tid	Po
Jin 2015(10)	T	37	Mecobalamin+ mosapride	6	71.0	5.1±1.7	-	0.5mg tid	Po
	T	37	Mecobalamin+ mosapride	6	71.0	5.1±1.7	-	5mg tid	Po
	C	37	Mosapride		71.0	4.9±1.6	-	5mg tid	Po
Li 2013(11)	T	28	Mecobalamin + cisapride	3	-	-	-	0.5mg qd	Im
	T	28	Mecobalamin + cisapride	3	-	-	-	5mg tid	Po
	C	28	Cisapride		-	-	-	5mg tid	Po
Li 2012(12)	T	36	Mecobalamin + mosapride	4	53.7	-	-	500mg qd	Im
	T	36	Mecobalamin + mosapride	4	53.7	-	-	10mg tid	Po
	C	36	Mosapride		54.3	-	-	10mg tid	Po
Li 2012(13)	T	52	Mecobalamin + etopril	4	-	-	-	0.5mg tid	Po
	T	52	Mecobalamin + etopril	4	-	-	-	50mg tid	Po
	C	44	Etopril		-	-	-	50mg tid	Po
Liu 2009(14)	T	30	Mecobalamin + mosapride	4	-	-	-	0.5mg qd	Im
	T	30	Mecobalamin + mosapride	4	-	-	-	5mg tid	Po
	C	28	Mosapride		-	-	-	5mg tid	Po
Mao 2017(15)	T	42	Mecobalamin+ mosapride	6	68.4±4.7	-	-	0.5mg tid	Po
	T	42	Mecobalamin+ mosapride	6	68.4±4.7	-	-	5mg tid	Po
	C	42	Mosapride		65.4±3.6	-	-	5mg tid	Po
Qiao 2009(16)	T	38	Mecobalamin+ cisapride	4	56.0±8.5	8.2±2.1	8.7±3.2	0.5mg qd	Im
	T	38	Mecobalamin+ cisapride	4	56.0±8.5	8.2±2.1	8.7±3.2	10mg tid	Po
	C	34	Cisapride		54.0±8.9	8.5±2.6	9.0±3.3	10mg tid	Po
Ren 2010(17)	T	24	Mecobalamin+ mosapride	4	56.0±8.4	-	-	0.5mg qd	Im
	T	24	Mecobalamin+ mosapride	4	56.0±8.4	-	-	10mg tid	Po
	C	21	Mosapride		54.0±8.6	-	-	10mg tid	Po
Shi 2018(18)	T	43	Mecobalamin + mosapride	6	66.4±5.6	1.9±0.4	6.9±0.9	0.5mg tid	Po
	T	43	Mecobalamin + mosapride	6	66.4±5.6	1.9±0.4	6.9±0.9	5mg tid
	C	43	Mosapride		65.9±6.1	1.9±0.4	7.1±1.1	5mg tid	Po
Sun 2011(19)	T	36	Mecobalamin + etopril	4	59.4±14.3	17.1±2.1	7.6±0.8	0.5mg qd	Im
	T	36	Mecobalamin + etopril	4	59.4±14.3	17.1±2.1	7.6±0.8	50mg tid	Po
	C	39	Etopril		65.0±13.0	15.1±2.5	6.9±0.6	50mg tid	Po
Tian 2006(20)	T	45	Mecobalamin + cisapride	4	-	-	-	0.5mg qd	Im
	T	45	Mecobalamin + cisapride	4	-	-	-	10mg tid	Po
	C	30	Cisapride		-	-	-	10mg tid	Po
Wang 2013(21)	T	72	Mecobalamin + domperidone	4	62.3±6.1	10.6±1.1	-	0.5mg qd	Im
	T	72	Mecobalamin + domperidone	4	62.3±6.1	10.6±1.1	-	10mg tid	Po
	C	72	Domperidone		62.3±6.1	10.5±1.1	-	10mg tid	Po
Wu 2009(22)	T	48	Mecobalamin + mosapride	4	53.0	0.6	-	0.5mg qod	Im
	T	48	Mecobalamin + mosapride	4	53.0	0.6	-	5mg tid	Po
	C	24	Mosapride		50.0	0.5	-	5mg tid	Po
Wu 2016(23)	T	51	Mecobalamin + mosapride	6	57.3±5.5	9.4±4.2	-	0.5mg tid	Po
	T	51	Mecobalamin + mosapride	6	57.3±5.5	9.4±4.2	-	5mg tid	Po
	C	51	Mosapride		59.3±3.7	8.8±4.8	-	5mg tid	Po
Zhai 2008(24)	T	36	Mecobalamin + mosapride	4	-	-	-	0.5mg tid	Po
	T	36	Mecobalamin + mosapride	4	-	-	-	5mg tid	Po
	C	36	Mosapride		-	-	-	5mg tid	Po
Zhao 2016(25)	T	37	Mecobalamin + mosapride	4	-	-	-	0.5mg tid	Po
	T	37	Mecobalamin + mosapride	4	-	-	-	5mg tid	Po
	C	37	Mosapride		-	-	-	5mg tid	Po
Zhao 2016(26)	T	36	Mecobalamin + mosapride	6	70.1±3.3	7.5±2.4	-	0.5mg tid	Po
	T	36	Mecobalamin + mosapride	6	70.1±3.3	7.5±2.4	-	5mg tid	Po
	C	36	Mosapride		69.5±3.1	8.3±2.0	-	5mg tid	Po
Zhu 2018(27)	T	46	Mecobalamin + trimebutin maleate	4	59.3±7.9	-	-	0.5mg tid	Po
	T	46	Mecobalamin + trimebutin maleate	4	59.3±7.9	-	-	200mg tid	Po
	C	46	Trimebutin maleate		60.1±6.4	-	-	200mg tid	Po

T, treatment group; C, control group; d, day; w, week; po, oral; im, intramuscular injection; -, not available