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. 2022 Feb 8;5:119. doi: 10.1038/s42003-022-03065-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Time course of cumulative H⁺ production in the (a) H1 hESC, (b) K562, and (c) GM12878 cell lines, which were calculated using Eq. (1) (see Methods) following ref. ⁴⁷. The legend specifies differences in working volume and flask type among the cell lines. Measurements conducted for three culture flasks per cell line (three biological replicates each). Data points at each time point represent data for the three biological replicates.