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. 2022 Feb 8;8:56. doi: 10.1038/s41420-022-00837-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A From day 35 to day 40, rapamycin and MHY1485, which are mTORC1 inhibitor and activator, respectively, were administered daily to investigate the role of mTORC1 in RO. B Light microscopic images of control, rapamycin-treated, and MHY1485-treated ROs at indicated time-points of development. C The average diameter of ROs at indicated time points. Data are expressed by mean ± S.E.M. *p < 0.05 by the Kruskal–Wallis test with post hoc analysis. Scale bar, 100 μm.