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. 2022 Jan 26;13:817526. doi: 10.3389/fphar.2022.817526

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Copyright © 2022 Tang, Li, Zhang, Zhang, Sun, Zhu, Feng, Su, Yang, Li, Liu, Chen, Dai, Zheng, Li, Li, Zhao, Qiu, Ye, Liu, Zheng, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Punicalagin significantly ameliorates IMQ-induced psoriasis-like symptoms in vivo. (A) A schematic showing the experimental design. (B) Phenotypic appearances of mice back skin in Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups on day 8. (C) Histological changes of mice back skin in Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups. Scale bar, 200 μm. (D) Ki67 staining of mice back skin in Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups. Scale bar, 200 μm. (E) Histological analysis of acanthosis in Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups. (F) The numbers of Ki67 positive cells in lesion skin derived from mice treated with Vaseline/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN. **p < 0.01, ***p < 0.001, N.S., non-significant. One-way ANOVA with Student-Newman-Keuls method for (E, F). Data represent the mean ± S.E.M.