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. 2022 Jan 26;13:817526. doi: 10.3389/fphar.2022.817526

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Copyright © 2022 Tang, Li, Zhang, Zhang, Sun, Zhu, Feng, Su, Yang, Li, Liu, Chen, Dai, Zheng, Li, Li, Zhao, Qiu, Ye, Liu, Zheng, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Punicalagin attenuates the enhancement of IL-1β by suppressing NF-κB activation and caspase-1 expression in vivo. (A) The relative mRNA level of IL-1β in Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups. (B) The protein expression of IL-1β in Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups. (C, D) Immunohistochemical staining and statistical analysis of phosphorylated p65 (Ser536) in skin sections derived from the Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN group. Scale bars: 200 μm. (E) The expression of cleaved and total caspase-1 in skin sections derived from the Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN group. (F) The relative mRNA level of CXCL-1 (left) and CCL-20 (right) in the skin lesions from Control/IMQ/IMQ + DEX/IMQ + Vehicle/IMQ + PUN groups. *p < 0.05, ***p < 0.001, N.S., non-significant. One-way ANOVA with Student-Newman-Keuls method for (A, D, F). Data represent the mean ± S.E.M.