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Punicalagin alleviates psoriasis by inhibiting NF-κB-mediated IL-1β transcription and caspase-1-regulated IL-1β secretion. Punicalagin relieves psoriasis by inhibiting NF-κB activation and cleaved caspase-1 expression, which ultimately suppresses the transcription and secretion of IL-1β and consequently represses IL-1β-mediated inflammatory cascade in vitro and in vivo.
