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. 2022 Feb 8;12:2133. doi: 10.1038/s41598-022-05882-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between intrahepatic cccDNA and serum HBV markers. Twenty-four HBV-infected chimeric mice under various conditions were divided into the HBV infection as during spreading phase of partially infection (n = 8; #1–2, #13–16, #19, #20) and the stable phase of fully infection (n = 16; #3–12, #17–18, #22–24). The cccDNA contents were correlated with (A) serum HBsAg and (B) serum HBcrAg in each group. Characteristics of each mouse were described in Table S2.