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. 2022 Feb 8;12:2130. doi: 10.1038/s41598-022-05980-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of p38 activation in the cortex of the P301S mouse. (A-D) Representative images showing p38 activation (pp38. Green), microglia (Iba1. Red), astrocytes (GFAP. Cyan) and neurons (NeuN. White) in the cortex of WT and P301S animals from 2 to 12 months of age. White dashed boxes correspond to the amplified section (E). Dashed forms indicate pp38 colocalization with the different cell markers: pp38⁺Iba1⁺ (white) and pp38⁺NeuN⁺ (orange). Nuclei were labeled with DAPI (blue). Number of pp38⁺ cells in microglia (F), neurons (G), astrocytes (H) and remaining cells (I). (J) Representation of all cell populations together. n = 57 (6–9 mice per group). Graphs show mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001 from two-way ANOVA. Scale bars: 50 µm (A1) and 25 µm (E1).