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. 2022 Feb 8;13:731. doi: 10.1038/s41467-022-28417-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a–c The three-dimensional density maps of the complexes. d–f Cartoon presentations of the three complex structures with S1P, Siponimod, or LPA shown in spheres inside the orthosteric pockets, as well as their density maps on the sides. S1P₁ is colored in cyan or salmon, LPA₁ in green, Gα_i in orange, G_β in purple, and G_γ in light green.