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. 2022 Feb 8;13:731. doi: 10.1038/s41467-022-28417-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Cartoon representation of S1P₁ with the bound S1P in spheres, and rotated 90° to show the two binding modules of transmembrane (TM) helices indicated by dashed lines. c, d Slice through views of the ligand-binding pockets of S1P₁ with the side binding pockets B1, B2 and B3 indicated. e, h Residues involved in interacting with the hydrocarbon chain (e–h) or the polar head group (g, h) of S1P or Siponimod are shown in sticks.