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. 2022 Feb 8;13:731. doi: 10.1038/s41467-022-28417-2

Fig. 3. The orthosteric LPA-binding pocket of the active LPA1.

Fig. 3

a, b Cartoon representation of LPA1 with the bound LPA in spheres, and rotated 90° to show the two binding modules of transmembrane (TM) helices indicated by dashed lines. c Slice through view of the LPA-binding pocket. df Residues involved in interacting with the hydrocarbon chain (d, e) or the polar head group (f) of LPA are shown in sticks.