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. 2022 Feb 8;13:731. doi: 10.1038/s41467-022-28417-2

Fig. 6. S1P receptor classification and modeled structures.

Fig. 6

a Classification, sequence homologies, coupled G-proteins and other names of S1P GPCRs. b Slice views of the orthosteric binding sites of S1P1 and the modeled S1P2-5. c Docking of Siponimod into the five S1P receptors. * indicates the clashes.